Prof. Roland Stocker

Head
Vascular Biology Division

Phone+61 (2) 9295 8600
Fax+61 (2) 9295 8601
Emailr.stocker@victorchang.edu.au

Head, Vascular Biology Division, Victor Chang Cardiac Research Institute

Research Focus

Our research focuses on the hardening of blood vessels (a process also called atherosclerosis) that is the single major cause of heart attacks and stroke, and hence death, in Australia. We study the contribution of oxidative processes to atherosclerosis, and how the disease can be inhibited. We have identified a protein, the up-regulation of which affects many biological processes, resulting in the inhibition of disease in several animal models. We are now studying how a change in a single protein can have such multiple biological effects, with a focus on vascular health and disease. We also have discovered a novel protein that regulates the tone of blood vessels and blood pressure in conditions of inflammation, and are now seeking to better understand the underlying principles of this action. Finally, we have established a new Core Facility to assess oxidative stress in vitro and in vivo, and we are developing new methods and tools to apply this to cardiovascular and other research.  Click here to read more >>

 

Research Areas

Roland has been recognised as a “Redox Pioneer” by the journal Antiox Redox Signal for his contributions to the field of redox biology. His areas of expertise include low-molecular weight non-proteinaceous antioxidants (bile pigments, coenzyme Q10, vitamins C and E, tryptophan metabolites, flavonoids); probucol; oxidative modifications of lipoproteins (LDL, HDL) and their roles in the pathogenesis of atherosclerosis; the involvement of myeloperoxidase to endothelial dysfunction and atherosclerosis; the role of heme oxygenase-1 in vascular health and disease; the contributions of indoleamine 2,3-dioxygenase to antioxidant defence and the control of vascular tone/blood pressure; and animal models of atherosclerosis and related vascular diseases.  Click here to read more >>

 

 

Co-investigators

Dr Anita Ayer

Dr Preet Chadha

Dr Louise Dunn

Ms Hafizah Abdul Hamid

Dr Magdalena Lam

Dr Ghassan Maghzal

Dr Jun Ni

Dr Sudhir Shengule

Dr Cacang Suarna

Mr Darren Newington

Mr Di Zhang

Hypoxystation and metabolic reprogramming

... how cells change their metabolism to form new blood vessels in low oxygen environments.

publications

See Roland Stocker’s 20 most significant publications

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