Prof. Robert M Graham AO
Head of Cardiac Receptor Biology Laboratory
|Phone||02 9295 8602|
|Fax||02 9295 8601|
Robert M. Graham received his training in medicine at the University of New South Wales (MB,BS Hons, 1972; MD, 1988), St. Vincent’s Hospital, Sydney and Sydney Hospital (FRACP, 1979) and University of Texas Southwestern Medical School (UTSWMS), Dallas, Texas (FRCP, 1981). He was appointed as Assistant Professor, Department of Pharmacology, UTSWMS (Alfred Gilman, Chairman, Nobel Laureate) in 1978, and Associate Professor in Medicine, Cellular and Molecular Research Laboratory (Edgar Haber, Chairman), Massachusetts General Hospital and Harvard Medical School (1982). In 1988, he undertook a Sabbatical working with H. Gobind Khorana (Nobel Laureate) at the Massachusetts Institute of Technology. In 1989, he was appointed as Robert C. Tarazi Chairman, Department of Molecular Cardiology, Cleveland Clinic Foundation and Professor of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio. After 17 years in the US, he returned to Australia in 1994, as the inaugural Executive Director, Victor Chang Cardiac Research Institute and Professor of Medicine, UNSW.
Heart failure is a leading cause of morbidity and mortality in Australia and the United States, with 30-40% of people dying within one year of the diagnosis of heart failure. High blood pressure (hypertension) and loss of heart muscle cells after a heart attack (myocardial infarct) predispose patients to this syndrome. Current treatments are aimed at slowing the progression of this syndrome, however, there is a need to develop novel preventative and reparative therapies. One of our major interests is elucidating the molecular mechanisms underlying hypertrophy and heart failure, with specific focus on the adrenergic receptors, which have direct patho-physiological and therapeutic relevance. Our other major interest is in regeneration of damaged heart tissue after infarct and the therapeutic potential of stem cells for the management of heart muscle cell injury and cardiomyopathies.
1. Cardiac Regeneration
2. Cardiac Hypertrophy and Failure
3. Adrenergic receptor structure and function
Andrea Chan, BSc, BA
Sara Holman, BSc (Biomed)
Siiri E. Iismaa
Jianxin Wu, PhD
Xenia Kadonis, PhD
Amy Nicks, PhD
Nicola Smith, PhD
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