Heart attack breakthrough

Heart attack breakthrough

Researchers discover potential new tools to identify and treat people at high risk of heart attack

14 September 2018

World first research, led by the Victor Chang Cardiac Research Institute, has shown it may be possible to both identify those at risk of a heart attack and prevent it from occurring.

Heart attacks are a major cause of death in Australia and, on average, claim one life almost every hour.

The underlying cause of a heart attack is a build-up of plaque composed of fatty material and inflammatory cells on the inside of the heart’s arteries. Some plaques are ‘unstable’ and vulnerable to rupture, resulting in the formation of a clot that blocks blood flow to the heart. This causes a heart attack.

For decades, clinicians and scientist from around the globe have sought to distinguish dangerous plaques that are likely to rupture, from stable and dormant plaques.

Victor Chang Cardiac Imaging

Using a highly sophisticated mouse model, the Vascular Biology team at the Victor Chang Cardiac Research Institute discovered that the activity of an inflammatory enzyme, known as myeloperoxidase, is significantly higher in unstable compared to stable plaques.

The researchers then demonstrated that a magnetic resonance imaging (MRI) scan after injection of a chemical probe, can be used to accurately and selectively identify the presence of dangerous plaques in coronary arteries.

Administered into the blood stream, the chemical probe highlights dangerous plaque that has increased myeloperoxidase activity, like a neon sign. This makes it easily visible on an MRI scan.

No one has been able to do this before and it will provide doctors with early warning that they need to intervene.

The team investigated whether elevated enzyme activity causes plaque destabilization.

Heart Attack

“The results were really exciting! When we administered a drug that inhibits myeloperoxidase activity, we discovered it stabilized the plaque by making its lining sturdier and less prone to rupture. There was also decreased bleeding and clotting in the artery wall under the plaque."

The next steps in this exciting development are to adjust the chemical MRI probe for human use, and then carry out clinical trials to confirm the utility of both the new imaging techniques to identify, and myeloperoxidase inhibitors to treat, high-risk patients.

The research has been applauded by the Victor Chang Cardiac Research Institute’s Executive Director, Professor Bob Graham.

“This is a discovery that Australians should be very proud of. The MR imaging technique has the potential to be the first non-invasive method to provide information on coronary plaque activity, enabling researchers to potentially diagnose those at risk of a heart attack.

“Angiography is the current gold standard of coronary imaging, and while it can accurately define arterial narrowing it falls short and cannot identify other features of high-risk plaque. To translate the new tools into the clinic will take time, as well as funding that we are currently seeking,” Professor Graham revealed.

The research led by the Victor Chang Cardiac Research Institute was an international collaboration involving Melbourne’s Baker Heart and Diabetes Institute, the University of New South Wales, the National University of Singapore and the University of Otago.

Click here to access a copy of the paper, entitled “Myeloperoxidase is a Potential Molecular Imaging and Therapeutic Target for the Identification and Stabilisation of High-Risk Atherosclerotic Plaque” by Imran Rashid et al. European Heart Journal(doi:10.1093/eurheartj/ehy419).

Heart Attack Statistics

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Acknowledgement of Country

The Victor Chang Cardiac Research Institute acknowledges Traditional Owners of Country throughout Australia and recognises the continuing connection to lands, waters and communities. We pay our respect to Aboriginal and Torres Strait Islander cultures; and to Elders past and present.

Victor Chang Cardiac Research Institute - The Home of Heart Research for 30 Years