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Dr Ashish Mehta

Dr Ashish Mehta’s research focuses on using humanised in vitro models for studying patients with cardiovascular disease, using human induced pluripotent stem cells (hiPSCs) technology. These hiPSCs are differentiated into cardiovascular lineage like cardiomyocytes and endothelial cells to address basic molecular mechanisms regulating the disease or identifying new drug candidates for therapeutic applications.

His laboratory uses high throughput robotics and an array of high-end phenotyping tools. These tools are used to decipher the underlying molecular process involved in cardiovascular diseases from a single cell level to a tissue/organ level.

Dr Mehta completed his BSc (Hons) and MSc (Biotechnology) in 1998 and his PhD in Biochemistry in 2003 at Defence Research and Development Establishment, India. He then worked for a private company on applications of human embryonic stem cells as tools for drug screening.  In 2010, he moved to Singapore to work on induced pluripotent stem cells and their derived cardiomyocytes. His research focused on the molecular mechanism of a cardiac arrhythmogenic disorder, LQT2, and to discover compounds that could reverse this clinical phenotype.

Joining the Victor Chang Institute in 2017, Dr Mehta is Head of the iPSC and Phenotyping Research Laboratory within the Victor Chang Innovation Centre. 

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