Meet the Innovation Centre Team

Dr. Ismael Aguirre-Maclennan

Stem Cell Biologist, Manager of the Stem Cell Production Facility

Dr. Ismael Aguirre-Maclennan is a passionate stem cell biologist, with extensive experience in mammalian cells, pluripotent stem cell generation, maintenance, and banking.

Ismael moved from Peru to Australia in 2007 to continue his postgraduate studies at Monash and La Trobe University, where he completed his PhD in genetics. His PhD research focused on the derivation of marsupial induced pluripotent stem cells.

After graduating, Dr. Aguirre-Maclennan relocated to Thailand to work with human iPSCs. He was later recruited by the Victor Chang Cardiac Research Institute Innovation Centre where he now manages the Stem Cell Production Facility. He has a special interest in the application of gene-editing technologies for generating clinically relevant isogenic iPSCs and differentiated phenotypes for functional cell screening.

Ms Esther Kristianto

Instrument Operator

Ms Esther Kristianto has lengthy experience working with mass spectrometry (MS) instrumentation. She completed her BSc in Applied Chemistry at the University of Technology Sydney in 2007, training in multiresidue analysis.

In 2011, Ms Kristianto joined the South Australian node of Metabolomics Australia, housed within the Australian Wine Research Institute (AWRI). She was responsible for performing targeted analysis of metabolites in grapes and wines, as well as facilitating new method development in other biological matrices using GC-MS, LC-MS/MS and LC-qTOF.

Ms Kristianto later returned to Sydney and joined the newly established Metabolomics Facility in the Victor Chang Cardiac Research Institute Innovation Centre. She operates the LC-MS/MS instruments for targeted metabolomics analysis and work closely and collaboratively with researchers and students to develop new workflows and methods for their projects.

Dr. Vanessa Lanoue

Head, Micro Imaging Facility

Dr. Vanessa Lanoue is the Head of the Micro Imaging Facility at the Victor Chang Cardiac Research Institute Innovation Centre. Dr. Lanoue is an experienced microscopist, with expertise in fluorescent microscopy, X-ray micro-tomography, 3D and live microscopy and in silico prost processing and analysis.

Dr. Lanoue completed her PhD in Neuroscience in 2012, at the University Pierre and Marie Curie in Paris, France. She relocated to Brisbane, Australia, in 2014 where she undertook a postdoctoral position in neuronal development. There, she developed her skills in many forms of microscopy, and live fluorescent confocal imaging.

Dr. Lanoue moved to Sydney in 2019 to establish and lead the Micro Imaging Facility at the Innovation Centre. She collaborates with scientists and provides research support and training in specimen preparation, image acquisition, and post-processing and analysis of microscopy data obtained with the state-of-the-art instruments.

Dr. Jeffrey McArthur

Head, Cell Function & Screening Facility

Dr. Jeffrey McArthur is the Head of the Cell Function & Screening Facility within the Innovation Centre at the Victor Chang Cardiac Research Institute. Dr. McArthur is an experienced electrophysiologist, with expertise in ion channels underlying cellular excitability and various electrophysiological techniques to study them.

He completed his PhD in 2011 from the University of Calgary, Canada, where he trained in electrophysiological methods to study ion channels. Research fellow positions at RMIT University (2011-13) and Harvard University (2013-16) provided him with experience in Cav channels involved in sensory perception.

In 2019, while still developing his independent research on calcium channels, he joined the Victor Chang Cardiac Research Institute, as Head of the Cell Function & Screening Facility. Dr. McArthur brings valuable experience in ion channel physiology and pathophysiology as well as various electrophysiological methods, evidenced by his 24 publications in well-respected physiology/pharmacology journals.

Dr. Xiaosuo Wang

Metabolomics Research Scientist

Dr. Wang is a Metabolomics Research Scientist within the Innovation Centre at the Victor Chang Cardiac Research Institute. Her expertise is focused on the emerging and multi-disciplinary “Omics” projects, developing workflows encompassing proteomics, metabolomics and lipidomics.

Dr. Wang obtained her PhD in Medicine at the University of Sydney in 2009, investigating the protective role of apolipoproteins in HDL against cardiovascular diseases by utilising various analytical techniques including extensive MS methods.

She continued her MS journey during her postdoctoral work, studying post-translational modifications of myoglobin after acute myocardial infarct using MALDI-TOF and MALDI imaging MS. From 2013 to 2020, Dr. Wang was the Core Facility Manager of the Mass Spectrometry Facility within the Bosch Institute at the University of Sydney.